NLSdb: database of nuclear localization signals

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NLSdb: database of nuclear localization signals

NLSdb is a database of nuclear localization signals (NLSs) and of nuclear proteins. NLSs are short stretches of residues mediating transport of nuclear proteins into the nucleus. The database contains 114 experimentally determined NLSs that were obtained through an extensive literature search. Using 'in silico mutagenesis' this set was extended to 308 experimental and potential NLSs. This final...

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NLSdb—major update for database of nuclear localization signals and nuclear export signals

NLSdb is a database collecting nuclear export signals (NES) and nuclear localization signals (NLS) along with experimentally annotated nuclear and non-nuclear proteins. NES and NLS are short sequence motifs related to protein transport out of and into the nucleus. The updated NLSdb now contains 2253 NLS and introduces 398 NES. The potential sets of novel NES and NLS have been generated by a sim...

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Finding nuclear localization signals.

A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential NLSs. This final set matched in 43% of all known nuclear proteins and in no kn...

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Prediction of Nuclear Localization Signals by HMM

The transport of nuclear proteins is a very important step for the maintenance of life. Most proteins that function in the nucleus are moved through the nuclear envelope that is penetrated by the nuclear pores. The nuclear pore is formed by a large, complex structure known as the nuclear pore complex (NPC). The NPC is a major gateway for mediating ions, small molecules, proteins, RNAs, and ribo...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2003

ISSN: 1362-4962

DOI: 10.1093/nar/gkg001